Diastereoconvergent Synthesis of trans-5-Hydroxy-6-Substituted-2-Piperidinones by Addition–Cyclization–Deprotection Process
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https://figshare.com/articles/dataset/Diastereoconvergent_Synthesis_of_i_trans_i_5_Hydroxy_6_Substituted_2_Piperidinones_by_Addition_Cyclization_Deprotection_Process/2264425
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资源简介：
A diastereoselective one-pot approach to access trans-5-hydroxy-6-substituted-2-piperidinones by an addition–cyclization–deprotection process has been developed, in which the stereogenic center at the C-6 position was solely controlled by α-OTBS group. The utility of this transformation is demonstrated by the asymmetric synthesis of the enantiomer of (−)-CP-99,994.
创建时间：
2016-02-17
