Primordial Prevention of Gestational Diabetes Mellitus A Novel Approach

Objective: Pregnant women should be tested for Post-Prandial Blood Glucose(PPBG) by the 8th week (2 months) with the value of 2hr PPBG 110 mg/dl as a Cut-off so that adequate time is available to control blood glucose within this range otherwise; fetal insulin will start secreting if blood glucose goes beyond 110 mg/dl by 11th week, and therefore within this crucial period blood glucose can be controlled with medical nutrition therapy(MNT), exercise, and Metformin 250 mg twice daily throughout pregnancy.

研究目标：孕妇需于妊娠第8孕周（即妊娠2个月）前接受餐后血糖（Post-Prandial Blood Glucose, PPBG）检测，以2小时餐后血糖值110 mg/dl作为截断临界值（Cut-off），从而预留充足时间将血糖控制在该范围内；若在妊娠第11孕周时血糖高于110 mg/dl，则胎儿将开始分泌胰岛素，因此在此关键窗口期内，可通过医学营养治疗（medical nutrition therapy, MNT）、运动干预，以及整个孕期每日两次服用250mg二甲双胍（Metformin）的方式控制血糖。