Human Heat Shock Protein 90 bound to 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide

Human Heat Shock Protein 90 bound to 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide Descriptor: 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide, Heat shock protein HSP 90-alpha Authors: Schuetz, D.A, Richter, L, Amaral, M, Grandits, M, Musil, D, Graedler, U, Frech, M, Ecker, G.F. Deposit date: 2017-07-03 Release date: 2018-05-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors. J. Med. Chem., 61, 2018

结合有6-羟基-3-(3-甲基苄基)-1H-吲唑-5-羧酸(4-吗啉-4-基苯基)酰胺的人源热休克蛋白90（Heat Shock Protein 90, HSP90）。描述符：6-羟基-3-(3-甲基苄基)-1H-吲唑-5-羧酸(4-吗啉-4-基苯基)酰胺、热休克蛋白90α（HSP 90-alpha）。作者：Schuetz, D.A、Richter, L、Amaral, M、Grandits, M、Musil, D、Graedler, U、Frech, M、Ecker, G.F.。存档日期：2017年7月3日。发布日期：2018年5月23日。最后修改日期：2024年5月8日。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.62埃）。引用文献：《配体去溶剂化调控热休克蛋白90（Hsp90）抑制剂的结合速率与药物驻留时间》，J. Med. Chem., 61, 2018