Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.

Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines. Descriptor: 4-hydroxy-3-nitro-5-{[4-(trifluoromethyl)phenyl]carbamamido}benzene-1-sulfonamide, Carbonic anhydrase 2, ZINC ION Authors: Singh, S, McKenna, R, Supuran, C.T, Nocentini, A, Lomelino, C, Lucarini, E, Bartolucci, G, Mannelli, L.D.C, Ghelardini, C, Gratteri, P. Deposit date: 2018-08-06 Release date: 2018-11-28 Last modified: 2026-04-15 Method: X-RAY DIFFRACTION (1.88 Å) Cite: 4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles. J. Med. Chem., 61, 2018

生物还原型4-羟基-3-硝基-5-脲基苯磺酰胺类化合物可选择性靶向肿瘤相关碳酸酐酶（Carbonic anhydrase）同工酶IX与XII，且对人类癌细胞系展现出缺氧增强的细胞毒性。描述符：4-羟基-3-硝基-5-{[4-(三氟甲基)苯基]氨基甲酰氨基}苯-1-磺酰胺、碳酸酐酶2（Carbonic anhydrase 2）、ZINC ION。作者：Singh, S、McKenna, R、Supuran, C.T、Nocentini, A、Lomelino, C、Lucarini, E、Bartolucci, G、Mannelli, L.D.C、Ghelardini, C、Gratteri, P。入库日期：2018-08-06；发布日期：2018-11-28；最后修改日期：2026-04-15。检测方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.88埃）。引用文献：《4-羟基-3-硝基-5-脲基苯磺酰胺类化合物可选择性靶向肿瘤相关碳酸酐酶同工酶IX和XII并展现缺氧增强的抗增殖活性》，载于《药物化学杂志》（J. Med. Chem.），第61卷，2018年。