Obligate endosymbiosis explains genome expansion during eukaryogenesis

The endosymbiosis of an alpha-proteobacterium that gave rise to mitochondria was one of the key events in eukaryogenesis. One striking outcome of eukaryogenesis was a much more complex cell with a large genome. Despite the existence of many alternative hypotheses for this and other patterns potentially related to endosymbiosis, a constructive evolutionary model in which these hypotheses can be studied is still lacking.
Here, we present a new theoretical approach in which we focus on the consequences rather than the causes of the mitochondrial endosymbiosis. Using a constructive evolutionary model of cell-cycle regulation, we find that genome expansion and genome size asymmetry arise from emergent host–symbiont cell-cycle coordination. We also find that holobionts with large host and small symbiont genomes perform best on long timescales, and mimic the outcome of eukaryogenesis.
By designing and studying a constructive evolutionary model of obligate endosymbiosis, we uncovered some of th..., Genomes are beads-on-a-string virtual genomes evolved using a computational model, available on github as Eukaryotes: github.com/samvonderdunk/Eukaryotes,