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Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients

ChEBI2019-09-21 更新2026-07-12 收录

肿瘤耐药基因组学

结直肠癌靶向治疗

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-8340 数据链接链接失效反馈

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资源简介：

Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients

应用场景：

创建时间：

2019-09-21

结直肠癌靶向治疗

老年肿瘤临床试验

OBJECTIVE: The principal objective of the trial is to evaluate whether the addition of cetuximab associated with 5-fluorouracil in elderly patients with KRAS wild type advanced colorectal cancer (CRC)

NIAID Data Ecosystem70

Design and Synthesis of a 2‑Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy

CDK8抑制剂

结直肠癌靶向治疗

CDK8 is a transcriptional cyclin-dependent kinase and considered as a potential target in colon cancer therapeutics. Here, a novel selective CDK8 inhibitor was identified against colon cancer in vivo.

Figshare60

Phase II study of chemotherapy with Capecitabine/Bevacizumab in elderly patients with advanced and recurrent colorectal cancer

结直肠癌靶向治疗

老年肿瘤疗效评估

Interventions: Capecitabine plus bevacizumab therapy Capecitabine:2,000mg/m2 twice daily (orally, day1 after dinner:day8 after breakfast) Bevacizumab:7.5mg/kg day 1 The treatment is repeated every thr

NIAID Data Ecosystem30

Study of Bevacizumab Plus Chemotherapy in Patients With Metastatic Colorectal Cancer

生物标志物预测

结直肠癌靶向治疗

This study evaluates the relationship of biomarker expression and efficacy of bevacizumab plus chemotherapy in patients with unresectable/metastatic colorectal cancer. Before the treatment, the invest

NIAID Data Ecosystem60

A Study of Cetuximab in Patients Who Have Stage IV Colorectal Cancer

结直肠癌靶向治疗

药物安全性评估

The purpose of this clinical research study is to learn about the safety of cetuximab in patients with stage IV colorectal cancer, and who may benefit from cetuximab.

NIAID Data Ecosystem30

Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients

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