Supplement material from: Plasma levels of triglycerides and IL6 are associated with weight regain and fat mass expansion

Background/Objective: Long-term weight loss (WL) maintenance is the biggest challenge for overweight and obesity due to the almost unavoidable phenomenon of partial or even total weight regain (WR) after WL. In the current study we investigated the relations of (the changes of) adipocyte size and other risk biomarkers with WR during the follow up of the Yoyo dietary intervention.
Design: In this randomized controlled study, 48 overweight/obese participants underwent a (very) low calorie diet to lose weight, followed by a weight stable period of 4 weeks and a follow-up period of 9 months. Anthropometric measurements, adipocyte volume of abdominal subcutaneous adipose tissue and plasma metabolic parameters (FFA, TG, total cholesterol, glucose, insulin, HOMA-IR, IL6, ACE activity, RBP4) at the beginning and the end of the follow-up were analyzed.
Results: Our results show that changes of TG, IL6, HOMA-IR and ACE are significantly positively correlated with WR. Multiple linear regression an...

背景与研究目标：对于超重与肥胖人群而言，长期体重减轻（Weight Loss，WL）后的维持是最严峻的挑战，这是由于体重减轻后几乎不可避免地会出现部分甚至全部的体重反弹（Weight Regain，WR）现象。本研究旨在探究Yoyo膳食干预随访过程中，脂肪细胞大小变化及其他风险生物标志物与体重反弹的关联。
研究设计：本研究为随机对照试验，共纳入48名超重/肥胖受试者，先接受（极）低热量饮食以实现体重减轻，随后进入为期4周的体重稳定期，再开展为期9个月的随访。分别于随访起始与结束阶段，对人体测量学指标、腹部皮下脂肪组织的脂肪细胞体积以及血浆代谢参数：游离脂肪酸（Free Fatty Acid，FFA）、甘油三酯（Triglyceride，TG）、总胆固醇、葡萄糖、胰岛素、胰岛素抵抗稳态模型评估指数（Homeostasis Model Assessment of Insulin Resistance，HOMA-IR）、白细胞介素6（Interleukin 6，IL6）、血管紧张素转换酶（Angiotensin Converting Enzyme，ACE）活性、视黄醇结合蛋白4（Retinol Binding Protein 4，RBP4）进行了分析。
研究结果：本研究结果显示，甘油三酯（TG）、白细胞介素6（IL6）、胰岛素抵抗稳态模型评估指数（HOMA-IR）与血管紧张素转换酶（ACE）的变化量与体重反弹呈显著正相关。多元线性回归分析……