BioBrAIn: Stavanger 22m3 bioreactor - CFD-derived data

Access to publicly available detailed information on industrial-scale fermentors is limited; most studies date back to the 1980s and 1990s, before the widespread availability of affordable computing power. Among these, the EU-Project "Bioprocess Scale-up Strategy" analyzed a 30 cubic meter reactor design for a fed-batch process with a maximum working volume of 22 cubic meters equipped with Rushton Turbine (RT) impellers. Here, we focus on the configuration using solely RT-impellers. The studies by Bylund et al. and Vrábel et. al provide detailed descriptions of the reactor geometry, pulse-response experiments for mixing time determination, and the process conditions. Notably, the available data spans a wide range of operating conditions—both aerated and non-aerated—resulting in distinct impeller flow regimes (i.e., flooding, loading, and transitional states). <br>Based on these studies, CFD simulations were conducted across the operating conditions summarized in the `dp_op_conditions.csv` file and also the README.md file. Further information on the dimensions of the stirred tank, mesh, and model parameterization can be found in the README.md file and config.json files per design point, respectively. <br>The accompanying documentation for the entire data collection (database) and a visualization manual can be found in DOI: <strong>10.4121/27fd363b-1310-4a69-9635-aa50d9bb7823</strong><br>This dataset is part of the <strong>BioBrAIn </strong>collection -<em> A CFD database of bioreactors </em>(DOI: <strong>10.4121/b99ff905-7bfa-4d13-a429-e2daad2d7579)</strong>.This project was supported by the 4th edition of the FAIR Data Fund from 4TU.ResearchData.

公开可得的工业规模发酵罐详细资料相对匮乏；多数相关研究可追溯至20世纪80至90年代，彼时廉价算力尚未得到广泛应用。其中，欧盟项目「生物过程放大策略」（Bioprocess Scale-up Strategy）针对一款补料分批工艺的30立方米反应器设计开展分析，该反应器最大工作容积为22立方米，配备鲁式涡轮（Rushton Turbine, RT）搅拌桨。本数据集聚焦于仅采用RT搅拌桨的配置方案。Bylund等人与Vrábel等人的研究对反应器几何结构、用于测定混合时间的脉冲响应实验以及工艺条件均有详细记述。值得注意的是，现有数据覆盖了宽泛的操作工况范围——涵盖曝气与非曝气工况——由此形成了不同的搅拌桨流态，即淹流、载流与过渡状态。
基于上述研究，本数据集针对`dp_op_conditions.csv`文件与README.md文件中汇总的全部操作工况开展了计算流体动力学（Computational Fluid Dynamics, CFD）模拟。关于搅拌槽、网格的尺寸信息，以及各设计点的模型参数化细节，可分别查阅README.md文件与对应的config.json文件。
整套数据集（数据库）的配套说明文档与可视化操作手册可在DOI：<strong>10.4121/27fd363b-1310-4a69-9635-aa50d9bb7823</strong>处获取。本数据集隶属于<strong>BioBrAIn</strong>数据集集合——<em>生物反应器计算流体动力学数据库</em>（DOI：<strong>10.4121/b99ff905-7bfa-4d13-a429-e2daad2d7579</strong>）。本项目得到了4TU.ResearchData的第4届FAIR数据基金支持。