Transgenerational inheritance of diminished ovarian reserve triggered by prenatal propylparaben exposure in mice (PRJCA042076)

Preliminary animal studies in this project revealed that prenatal propylparaben exposure induces diminished ovarian reserve persisting transgenerationally in F1-F3 offspring. By integrating multi-generational whole-genome bisulfite sequencing (WGBS) and RNA sequencing (RNA-seq), this study aims to uncover the epigenetic molecules mediating this transgenerational inheritance in oocytes and elucidate downstream mechanisms. These findings will provide theoretical foundations for tracing etiology, enabling early prevention, and developing genetic interventions for diminished ovarian reserve.