Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1347

Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1347 Descriptor: (7S)-7-methyl-2-{[3-(piperidin-1-yl)propyl]sulfanyl}-7,8-dihydro[1]benzothieno[2,3-d]pyrimidin-4-amine, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... Authors: Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. Deposit date: 2020-02-16 Release date: 2020-06-03 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020

结核分枝杆菌（Mycobacterium tuberculosis）来源的Eis蛋白与抑制剂SGT1347复合物的晶体结构。描述符：(7S)-7-甲基-2-{[3-(1-哌啶基)丙基]硫烷基}-7,8-二氢[1]苯并噻吩并[2,3-d]嘧啶-4-胺、二(羟乙基)醚（DI(HYDROXYETHYL)ETHER）、二甲基亚砜（DIMETHYL SULFOXIDE）等。作者：Punetha A、Hou C、Ngo H.X、Garneau-Tsodikova S、Tsodikov O.V.。存储日期：2020-02-16；发布日期：2020-06-03；最后修改日期：2023-10-11。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.6 Å。引用文献：《结核分枝杆菌乙酰基转移酶Eis抑制剂的结构导向优化》，发表于Acs Chem.Biol.，第15卷，2020年。