Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with the 5-[(morpholin-4-yl)methyl]quinolin-8-ol inhibitor

Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with the 5-[(morpholin-4-yl)methyl]quinolin-8-ol inhibitor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(morpholin-4-ylmethyl)quinolin-8-ol, UDP-glucose-glycoprotein glucosyltransferase-like protein, ... Authors: Roversi, P, Zitzmann, N, Bayo, Y, Kantsadi, A.L, Chandran, A.V. Deposit date: 2022-04-15 Release date: 2023-04-26 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.649 Å) Cite: A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint. Iscience, 26, 2023来自嗜热毛壳菌（Chaetomium thermophilum）的UDP-葡萄糖基糖蛋白葡萄糖基转移酶（UDP-Glucose Glycoprotein Glucosyltransferase）催化结构域，与5-[(吗啉-4-基)甲基]喹啉-8-醇抑制剂形成的复合物 配体标识：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、5-(吗啉-4-基甲基)喹啉-8-醇、UDP-葡萄糖基糖蛋白葡萄糖基转移酶样蛋白…… 作者：Roversi P、Zitzmann N、Bayo Y、Kantsadi A.L.、Chandran A.V. 存档日期：2022-04-15 发布日期：2023-04-26 最后修改日期：2024-11-06 实验方法：X射线衍射（分辨率1.649埃） 引用文献：《UGGT的喹啉-8-醇亚毫摩尔抑制剂——内质网糖蛋白折叠质量质控检查点》，《Iscience》，第26卷，2023年