Synthesis of Multiple-Substituted Pyrroles via Gold(I)-Catalyzed Hydroamination/Cyclization Cascade

A gold-catalyzed cascade hydroamination/cyclization
reaction of
α-amino ketones with alkynes to form substituted pyrroles has
been developed. The method offers several advantages such as high
regioselectivity with the tested cases, wide functional group tolerance,
and easily accessible starting materials. The synthetic utility of
the obtained pyrrole products was demonstrated by their efficient
transformations to 2-vinylated pyrroles via gold-catalyzed intermolecular
hydroarylation.