RNA-seq of prostate cancer cell lines with acquired resistance to AKT inhibitors GDC-0068 (ATP competitive) or MK206 (allosteric)

Goal: Study resistance mechanisms to ATP-competitive vs. allosteric AKT inhibitors, in prostate cancer Methods: RNA-sequencing Results: Resistance to the ATP-competitive inhibitor GDC-0068 was driven by compensatory activity of parallel signaling pathways Overall design: Duplicate results of RNA-seq of the LNCaP prostate cell line (untreated or treated with either AKT inhibitor) and derived clones with acquired resistance to either AKT inhibitor