Bulk RNAseq of C1Q knockout TauP301S hippocampi

The effect of C1q knockout on brain gene expression was examined in non-transgenic and TauP301S mice. Complement pathway has been shown to play an important role in neurodegenerative diseases, and in-house data show that C1QC KO protects against neurodegeneration in Alzheimer's disease (AD) model. TauP301S mice have neuroinflammation and neurodegeneration in the brain and is AD model. The most severe pathology of this disease model is in hippocampus. Overall design: This experiment examines RNA expression profiles in mouse hippocampi bulk tissue from WT or C1QC KO mice crossed with TauP301S or non-transgenic mice.