Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with N1-{(3'R,4'R)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(3'-fluorophenethyl)ethane-1,2-diamine

Protein Data Bank Japan2023-09-06 更新2026-03-21 收录

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Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with N1-{(3'R,4'R)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(3'-fluorophenethyl)ethane-1,2-diamine Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-{(3R,4R)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-[2-(3-fluorophenyl)ethyl]ethane-1,2-diamine, ... Authors: Delker, S.L, Li, H, Poulos, T.L. Deposit date: 2009-09-18 Release date: 2010-05-05 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model. J.Am.Chem.Soc., 132, 2010

大鼠神经元型一氧化氮合酶（neuronal nitric oxide synthase）R349A突变体血红素结构域与N1-{(3'R,4'R)-4'-[(6''-氨基-4''-甲基吡啶-2''-基)甲基]吡咯烷-3'-基}-N2-(3'-氟苯乙基)乙烷-1,2-二胺的复合物结构组分描述：5,6,7,8-四氢生物蝶呤、乙酸根离子、N-{(3R,4R)-4-[(6-氨基-4-甲基吡啶-2-基)甲基]吡咯烷-3-基}-N'-[2-(3-氟苯基)乙基]乙烷-1,2-二胺，…… 作者：Delker S.L.、Li H.、Poulos T.L. 提交日期：2009-09-18 发布日期：2010-05-05 最后修改日期：2023-09-06 实验方法：X射线衍射（分辨率2.01 Å）引用文献：可有效预防动物模型中脑瘫表型的一氧化氮合酶抑制剂的意外结合模式，《美国化学会志》，132卷，2010年

创建时间：

2009-09-18