Discovery of BMS-986144, a Third Generation, Pan Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Protein Data Bank Japan2024-03-27 更新2026-03-21 收录

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Discovery of BMS-986144, a Third Generation, Pan Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection Descriptor: NS3/4A Protease, ZINC ION, [1,1,1-tris(fluoranyl)-2-methyl-propan-2-yl] ~{N}-[(1~{S},4~{R},6~{S},7~{Z},11~{R},13~{R},14~{S},18~{R})-13-ethyl-18-(7-fluoranyl-6-methoxy-isoquinolin-1-yl)oxy-11-methyl-4-[(1-methylcyclopropyl)sulfonylcarbamoyl]-2,15-bis(oxidanylidene)-3,16-diazatricyclo[14.3.0.0^{4,6}]nonadec-7-en-14-yl]carbamate Authors: Ghosh, K, Anumula, R, Kumar, A. Deposit date: 2020-09-26 Release date: 2020-12-16 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 63, 2020

用于治疗丙型肝炎病毒感染的第三代泛基因型（Pan Genotype）NS3/4A蛋白酶（NS3/4A Protease）抑制剂BMS-986144的发现描述：NS3/4A蛋白酶（NS3/4A Protease）、锌离子（ZINC ION）、[1,1,1-三氟-2-甲基丙-2-基] N-[(1S,4R,6S,7Z,11R,13R,14S,18R)-13-乙基-18-(7-氟-6-甲氧基异喹啉-1-基)氧基-11-甲基-4-[(1-甲基环丙基)磺酰基氨基甲酰基]-2,15-二氧代-3,16-二氮杂三环[14.3.0.0^{4,6}]十九碳-7-烯-14-基]氨基甲酸酯作者：Ghosh K、Anumula R、Kumar A 存储日期：2020-09-26 发布日期：2020-12-16 最后修改日期：2024-03-27 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.15埃（Å）引用文献：Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 63, 2020

创建时间：

2020-09-26