Underwater crosslinking laminous adhesives modulating MSCs differentiation for osteochondral repair. Rattus norvegicus

We adopt the liquid hydrophobic photocrosslinkable poly (lactide-co-propylene glycol-co-lactide) dimethacrylates (PmLnDMA) as the cartilage phase and polymer encapsulating methacrylated hydroxyapatite nanoparticles (PmLnDMA/MH) as the mineralized subchondral bone phase. We enhanced the mechanotransduction and growth factor-mediated signaling pathways by matching the mechanical properties of the two phases to that of native cartilage and bone via systematical modulation of the adhesives composition and encapsulated growth factors' release profile.