Mcm2-7 is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of its DNA Gate

Alliance of Genome Resources2026-08-01 收录

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Mcm2-7复合物功能

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https://www.yeastgenome.org/dataset/GSE38032 数据链接链接失效反馈

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Genome wide characterization of Mcm2-7 localization and origin activity for mrc1 and mcm mutant alleles.

Metabolic remodeling maintains a reducing environment for rapid activation of replication checkpoint

代谢重塑

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Nucleotide metabolism fuels normal DNA replication and is also primarily targeted by the DNA replication checkpoint when replication stalls. To reveal a comprehensive interconnection between genome ma

NIAID Data Ecosystem70

HU treated cells vs wildtype untreated cells (elutriation centrifugation synchronized cells). Schizosaccharomyces pombe

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细胞周期调控

DNA replication checkpiont kinase rad3 (human ATM/ATR-like kinase) and cds1 (human CHK2-like kinase) are known to restore stalled replication forks and prevent subsequent cell cycle progression during

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The TRESLIN-MTBP complex couples completion of DNA replication with S/G2 transition

细胞周期调控

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It has been proposed that ATR kinase senses the completion of DNA replication to initiate the S/G2 transition. In contrast to this model, we show here that the TRESLIN-MTBP complex prevents a prematur

NIAID Data Ecosystem30

HU treated cells vs wildtype untreated cells (asynchronized cells). Schizosaccharomyces pombe

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细胞周期调控

NIAID Data Ecosystem60

Helicase subunit Cdc45 targets the checkpoint kinase Rad53 to both replication initiation and elongation complexes after fork stalling. Helicase subunit Cdc45 targets the checkpoint kinase Rad53 to both replication initiation and elongation complexes after fork stalling

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Across eukaryotes, inhibition of the progression of the DNA replication machinery causes an S-phase checkpoint response. This response regulates multiple processes, including inhibition of replication

NIAID Data Ecosystem50

Mcm2-7 is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of its DNA Gate

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