Palladium-Catalyzed Stereoselective Formation of Substituted Allylic Thioethers and Sulfones

A general method is reported for
the stereoselective preparation
of highly functionalized allylic thioethers. This protocol is based
on a Pd-catalyzed thiolation of modular vinyl cyclic carbonate substrates
and features high (Z)-selectivity, good yields, minimal
waste, ample product scope, and operational simplicity. A one-pot
strategy was used for the stereoselective formation of pharma-relevant
allylic sulfones derived from their in situ prepared thioether precursors.