Eicosanoid metabolism via cytochrome P450 monooxygenases

This pathway is inspired by the LIPID MAPS>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with the bottom left side of Figure 1 from Dennis and Norris (2015 [https://www.ncbi.nlm.nih.gov/pubmed/26139350]). Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the third route, via CYP. Orange boxes represent peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

本路径受LIPID MAPS>Eicosanoids通路扩展路径展示[https://lipidmaps.org/pathway/pathways_maps]启发，并进一步结合了Dennis和Norris（2015[https://www.ncbi.nlm.nih.gov/pubmed/26139350]）图1的左下角。二十烷酸（AA）通过环氧化酶（COX）[https://www.wikipathways.org/index.php/Pathway:WP4347]、脂氧合酶（LOX）[https://www.wikipathways.org/index.php/Pathway:WP4348]或细胞色素P450单加氧酶（CYP）[https://www.wikipathways.org/index.php/Pathway:WP4349]代谢产生的一组大型化合物被称为二十烷酸类。该路径可视化了第三条途径，即通过CYP。橙色方框代表可能被二十烷酸激活的过氧化物酶体增殖激活受体（PPARs）。