Expression profile of rat kidney of fetuses with 19 days of gestation under chronic rotation of the photoperiod.

Previously, we reported that of pregnant dams rats exposure to continues light and rotation of photoperiod have detrimental effects on the mother, fetus and adult offspring, with changes in the expression profile of fetal heart and liver. We investigated whether the chronic rotation of the photoperiod (CPS) during gestation can modify the fetal kidney expression profile at gestational day 19 by Affymetrix microarray analysis. Pregnant rat females were separated randomly into two groups: LD group, pregnant females kept 12:12 photoperiod throughout gestation (n=6 mothers LD), and the second group was CPS (Chronic photoperiod shifting) corresponding to pregnant females (n=6 mothers CPS) kept under a rotation scheme of photoperiod. At E19 we evaluate the global fetal transcriptome by microarray analysis of pooled fetal kidney for each mother.