PI3K/AKT pathway is activated by miRNA-22 in the proliferative CLL subset (mRNA)

ChEBI2014-05-15 更新2026-07-21 收录

淋巴细胞白血病分子机制

PI3K/AKT信号通路调控

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-53236 数据链接链接失效反馈

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PI3K/AKT pathway is activated by miRNA-22 in the proliferative CLL subset (mRNA)

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2014-05-15

PI3K/AKT pathway is activated by miRNA-22 in the proliferative CLL subset (mRNA). Homo sapiens

慢性淋巴细胞白血病增殖亚群

PI3K/AKT信号通路调控

Understanding the crosstalk between malignant B-cells and their milieu could provide clues on the molecular and clinical biology of Chronic Lymphocytic Leukemia (CLL). Aiming to generate novel therape

NIAID Data Ecosystem50

Homo sapiens

淋巴细胞白血病分子机制

microRNA靶基因

MicroRNAs are known to inhibit gene expression by binding to the 3Â´UTR of the target transcript. Downregulation of miR-223 has been recently reported to have prognostic significance in CLL. However,

NIAID Data Ecosystem30

AID contributes to accelerated disease progression in the TCL1 mouse transplant model for CLL

淋巴细胞白血病分子机制

AID诱导耐药与疾病进展

Adaptive somatic mutations conferring treatment resistance and accelerated disease progression is still a major problem in cancer therapy. Also in CLL, patients receiving novel, efficient drugs freque

NIAID Data Ecosystem10

Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas

儿科肉瘤靶向治疗

PI3K/AKT信号通路调控

Pediatric bone and soft tissue sarcomas often display increased Akt phosphorylation through up regulation of insulin-like growth factor (IGF1) signaling. Additionally, Akt signaling has been linked to

Figshare2016-01-15 更新50

siRNA-mediated silencing of ETV6/RUNX1 increases the level of mature miR-181a-1.

淋巴细胞白血病分子机制

miRNA调控

(A) Stem-loop sequence of human precursor mir-181a-1. Mature miR-181a (red) and miR181a-1 (blue) are indicated. (B) Validation of miR-181a-1 expression in primary pre-B ALL samples (ETV6/RUNX1-positiv

NIAID Data Ecosystem10

PI3K/AKT pathway is activated by miRNA-22 in the proliferative CLL subset (mRNA)

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