Additional file 4: of Artificial association of memory events by optogenetic stimulation of hippocampal CA3 cell ensembles

Input-output function. Data of input-output function obtained from KA1::Cre and CA3-NR1 KO mice infected with AAV-EF1α::DIO-ChR2-mCherry in the CA3 region. Laser power and fEPSP amplitude at the time of getting maximum fEPSP amplitude and at the time of using 50% of this stimulation intensity are shown. There was no statistical difference of input-output function between the groups (50% stimulation intensity, unpaired Student’s t test; t6 = 0.6807, p = 0.5214; 100% stimulation intensity, unpaired Student’s t test; t6 = 0.8144, p = 0.4465; 50% fEPSP amplitude, unpaired Student’s t test; t6 = 0.6289, p = 0.5526; 100% fEPSP amplitude, t6 = 0.7006, p = 0.5098). (XLS 27 kb)