Life After Pediatric Sepsis Evaluation

The purpose of this prospective observational study was to describe short and long-term outcomes among children surviving septic shock. LAPSE investigated the intensity and duration of sepsis-associated morbidity that persists following the acute septic event. LAPSE described the post sepsis illness trajectory through Health Related Quality of Life (HRQL) and subject functional status (FS). LAPSE examined organ dysfunction, as well as individual and environmental characteristics that influenced these outcomes. We hypothesized that variation of HRQL and FS would be seen following survival of severe sepsis, enabling development of composite outcome measures for future trials of pediatric sepsis. This study found that 11% of the children died within 3 months of their septic shock episode. Additionally, duration of stay, cumulative vasoactive-inotropic scores, duration of mechanical ventilation, and other factors were associated with adverse outcomes.

本项前瞻性观察研究旨在描述感染性休克存活儿童的短期与长期转归。LAPSE研究旨在探究急性脓毒症事件后持续存在的脓毒症相关并发症的严重程度与持续时长。该研究通过健康相关生命质量（Health Related Quality of Life, HRQL）与受试者功能状态（Functional Status, FS）刻画了脓毒症后疾病轨迹。此外，LAPSE还考察了器官功能障碍，以及影响上述转归的个体与环境特征。本研究提出假设：重症脓毒症存活患者的健康相关生命质量与功能状态存在异质性，这可为未来儿科脓毒症临床试验开发复合结局指标提供支撑。研究结果显示，11%的儿童在感染性休克发作后3个月内死亡。同时，住院时长、累积血管活性-正性肌力药物评分、机械通气时长及其他多项因素均与不良转归显著相关。

搜集汇总

背景与挑战

背景概述

该数据集是一个关于儿童脓毒症休克幸存者短期和长期结果的前瞻性观察性研究，包含391名婴儿和儿童受试者的临床、功能和生活质量数据，覆盖从入院到12个月的多个评估时间点。数据集旨在探索脓毒症后发病轨迹，并识别与不良结果相关的因素，所有数据公开可用且无访问限制。