Post stimulation immune response in suspected ZC3H12A deficiency

ZC3H12A deficiency has not been reported in humans yet but mechanistic in vitro as well as mouse study data show strong evidence that ZC3H12A acts as a negative immune regu;ator This series contains RNA sequencing data from primary fibroblasts obtained from patients with DBR1 deficiency, including mock-treated vs virus-infected cells. Cells from healthy unrelated controls and patients with STAT1 or TLR3 deficiency were analyzed for comparison. Overall design: Stimulation of PBMCs from two patients (brothers), two unaffected siblings and 4 unrelated, healthy controls for two hours with LPS/R848/IL1B or TNFa or left untreated.