Table_1_Risk Factors for Survival in Patients With Medulloblastoma: A Systematic Review and Meta-Analysis.doc

BackgroundConventional parameters show limited and unreliable correlations with medulloblastoma prognosis.AimTo evaluate the factors influencing overall survival (OS), event-free survival (EFS), and progression-free survival (PFS) in patients with medulloblastoma.MethodsPubMed, EMBASE, the Cochrane Library, and Web of Science were searched for studies published up to May 2021. The associations between various clinical and treatment factors and survival parameters were assessed.ResultsTwenty-nine studies (8455 patients) were included. Desmoplastic medulloblastoma (HR=0.41, 95%CI: 0.31-0.56), M0 disease (HR=2.07, 95%CI: 1.48-2.89), WNT, SSH, group 4 (all P

背景：传统参数与髓母细胞瘤的预后相关性有限且不可靠。目标：评估影响髓母细胞瘤患者总生存期（OS）、无事件生存期（EFS）和无进展生存期（PFS）的因素。方法：检索了截至2021年5月发布的PubMed、EMBASE、Cochrane图书馆和Web of Science数据库中的研究。评估了各种临床和治疗因素与生存参数之间的关联。结果：纳入了29项研究（8455名患者）。化生性髓母细胞瘤（HR=0.41，95%CI：0.31-0.56）、M0期疾病（HR=2.07，95%CI：1.48-2.89）、WNT、SSH、第4组（所有P值均显著）等与生存参数相关。