Cutaneous Cyst Number and Genotype of 215 (LE/Stm x BN) F2 Rats

There is evidence that the development of multiple cutaneous cysts (benign skin tumors) is heritable . Using inbred BN rats susceptible to chemically induced cutaneous cyst development and resistant LE/Stm rats we were able to establish a new animal model for genetic dissection of multiple cyst formation. We used a (LE/Stm x BN)F2 Generation treated with MNU for QTL mapping. The data presented in the table repesent genome-wide genotypes of 106 SNPs for 215 F2 rats. Additionally the number of cutaneous cysts was listed for each F2 animal.

已有证据表明，多发性皮肤囊肿（cutaneous cysts，良性皮肤肿瘤（benign skin tumors））的发生具有遗传性。本研究选取对化学诱导皮肤囊肿易感的近交系BN大鼠，以及对该囊肿发生具有抗性的LE/Stm大鼠，成功构建了可用于多发性囊肿形成遗传解析的新型动物模型。我们采用经N-甲基-N-硝基脲（MNU）处理的(LE/Stm × BN)F2代群体开展数量性状基因座（Quantitative Trait Locus, QTL）定位分析。本表格所呈现的数据为215只F2代大鼠的106个单核苷酸多态性（Single Nucleotide Polymorphism, SNPs）位点的全基因组基因型。此外，表格中还列出了每只F2代大鼠的皮肤囊肿数量。