Il-1-dependent enteric gliosis guides intestinal inflammation and dysmotility and modulates macrophage function

IL-1 signaling in enteric glia initiates acute intestinal inflamation and modulates postoperative motility disturbances by triggering a reactive glial phenotype named enteric gliosis. Enteric glia modulate macrophage function and activity in this reactive state by releasing a unique panel of chemokines and cytokines. An enteric glia-selective knockout of this pathway ameliorates acute postoperative inflammation and prevents postoperative ileus. Overall design: Examination of enteric glial cells after IL-1b treatment in vitro and the effect of conditioned medium on BMDMs from IL1R1-KO animals