GLYCATED HEMOGLOBIN AND FRUCTOSAMINE IN DOGS WITH DIABETES MELLITUS

Abstract Diabetes mellitus (DM) commonly occurs in dogs, and the laboratorial confirmation is carried out by glycemia test. The diagnosis and monitoring in humans is made by glycated hemoglobin and fructosamine concentrations. The objective of this study was to diagnose DM in 19 dogs, by evaluating seric glucose, glycated hemoglobin and fructosamine concentrations. Six dogs with DM and treated with insulin were assisted during a twelve-month period, by means of the same blood analysis, until the death (three dogs) or glycemic control (three dogs). Glucose, glycated hemoglobin and fructosamine increased in all dogs with DM, and dogs that did not survive presented higher glycated hemoglobin and seric glucose values than those that survived at the last evaluation. The results showed the importance of evaluating glycated hemoglobin and fructosamine in dogs with DM to diagnose and control treatment effectiveness.

摘要：糖尿病（Diabetes mellitus, DM）在犬类中较为常见，其实验室确诊依靠血糖检测。人类糖尿病的诊断与监测通常采用糖化血红蛋白（glycated hemoglobin）与果糖胺（fructosamine）浓度作为核心指标。本研究旨在通过检测血清葡萄糖、糖化血红蛋白及果糖胺浓度，对19只犬开展糖尿病确诊工作。6只确诊糖尿病且接受胰岛素治疗的患犬被纳入为期12个月的随访，期间重复进行相同的血液检测，直至其死亡（3只）或实现血糖控制（3只）。所有糖尿病患犬的葡萄糖、糖化血红蛋白及果糖胺水平均出现升高；末次评估阶段，未存活患犬的糖化血红蛋白与血清葡萄糖水平显著高于存活患犬。本研究结果表明，检测糖尿病患犬的糖化血红蛋白与果糖胺水平，对于犬类糖尿病的诊断及治疗效果监控具有重要临床价值。