Role of Diet in the Reconstitution of the Human Gut Microbiome and its Metabolome

Gut microbiota metabolites may be important for health yet studies are lacking that broadly correlate the composition of the human gut microbiome with the production of fecal metabolites and their impact on the plasma metabolome. Since gut microbiota metabolites are influenced by diet, we studied the impact of three divergent diets, vegan, omnivore, and a synthetic enteral nutrition (EEN) diet lacking fiber, on the human gut microbiome and its metabolome in a longitudinal analysis that included a microbiota depletion intervention.