PRL2 deficiency alters FLT3 mediated gene transcription in murine hematopoietic stem and progenitor cells. PRL2 deficiency alters FLT3 mediated gene transcription in murine hematopoietic stem and progenitor cells

To gain insights into the molecular mechanisms underlying the role of PRL2 in hematopoietic stem and progenitor cells (HSPCs), we performed RNA-seq analysis to compare gene expression in Prl2+/+ and Prl2-/- fetal liver cells which are enrich with HSPCs. Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of triplecate E14.5 fetal liver cells in each Prl2+/+ and Prl2-/- group .Comparative gene expression profiling analysis of RNA-seq data for E14.5 fetal liver cells Prl2-/-.