Loss of TGFβ signaling in the perichondrium drives longitudinal bone overgrowth in mice with Marfan syndrome. Loss of TGFβ signaling in the perichondrium drives longitudinal bone overgrowth in mice with Marfan syndrome

The goal of this study is to define the main tissue and mechanism implicated in the long bone overgrowth phenotype in mice with Marfan syndrome Overall design: RNAsequencing of perichondrium microdissected from WT and Fbn1Scx-/- mice