Dataset related to article "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions"

This record contains data related to article "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions" Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer. Indeed, the transcriptomic profiles of NKG2A+ and NKG2A- cells characterize two distinct "intralineages" of Vδ2 T lymphocytes that appear early during development, keep their phenotypes, and show self-renewal capabilities in adult life. The hyper-responsiveness of NKG2A+ Vδ2 T cells is counterbalanced by the inhibitory signaling delivered by human leukocyte antigen E (HLA-E) expressed on malignant cells as a tumor-escape mechanism. However, either masking or knocking out NKG2A restores the capacity of Vδ2 T cells to exert the highest effector functions even against HLA-E+ tumors. This is highly relevant in the clinic, as the different degrees of engagement of the NKG2A-HLA-E checkpoint in hepatocellular carcinoma, glioblastoma, and non-small cell lung cancer directly impact patients' overall survival. These findings open avenues for developing combined cellular and immunologic anticancer therapies.本数据集包含与论文《NKG2A表达可鉴定出具有最强抗肿瘤效应功能的人类Vδ2 T细胞（Vδ2 T cells）亚群》相关的数据。人类Vδ2 T细胞是一类天然样γδ T细胞（γδ T cells）效应细胞，可针对肿瘤发挥强效免疫监视作用。NKG2A的组成型表达可鉴定出一类Vδ2 T细胞亚群，该亚群天生具有固有抗癌高反应性。转录组谱（transcriptomic profiles）分析显示，NKG2A阳性与NKG2A阴性的Vδ2 T淋巴细胞分别属于两种截然不同的Vδ2 T细胞谱系内亚型；这类亚型在发育早期即已出现，可稳定维持自身表型，并在成年个体中仍保留自我更新能力。NKG2A阳性Vδ2 T细胞的高反应性会被恶性细胞表达的人类白细胞抗原E（HLA-E）所传递的抑制信号抵消，而这正是肿瘤的免疫逃逸机制之一。不过，无论是封闭还是敲除NKG2A，均可恢复Vδ2 T细胞针对HLA-E阳性肿瘤发挥最强效应功能的能力。这一发现具有重要临床价值：在肝细胞癌（hepatocellular carcinoma）、胶质母细胞瘤（glioblastoma）与非小细胞肺癌（non-small cell lung cancer）中，NKG2A-HLA-E免疫检查点（checkpoint）的不同激活程度会直接影响患者的总生存期（overall survival）。上述研究结果为开发联合细胞免疫与抗肿瘤免疫疗法开辟了全新方向。