The Cancer Genome Atlas Breast Invasive Carcinoma Collection (TCGA-BRCA)

The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from The Cancer Genome Atlas (TCGA). Clinical, genetic, and pathological data resides in the Genomic Data Commons (GDC) Data Portal while the radiological data is stored on The Cancer Imaging Archive (TCIA). Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes. Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type. For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial.

癌症基因组图谱乳腺浸润癌（The Cancer Genome Atlas Breast Invasive Carcinoma, TCGA-BRCA）数据集是一项更大规模研究计划的组成部分，该计划旨在构建以癌症表型与基因型关联为核心的研究共同体，具体方式为匹配癌症基因组图谱（The Cancer Genome Atlas, TCGA）受试者的临床影像数据。临床、遗传与病理数据存储于基因组数据共享（Genomic Data Commons, GDC）数据门户，而放射影像数据则留存于癌症影像档案库（The Cancer Imaging Archive, TCIA）。匹配后的TCGA患者标识符可支持研究人员在TCGA与TCIA数据库中探索组织基因型、放射影像表型与患者预后之间的关联关系。TCGA的组织样本采集自全球各地的众多站点，以达成其入组目标——每类癌症通常需采集约500份标本。正因如此，该影像数据集在扫描模态、设备厂商与采集协议方面均呈现出极强的异质性。在绝大多数情况下，这些影像均为常规诊疗流程中采集所得，而非受控研究或临床试验的组成部分。

搜集汇总

背景与挑战

背景概述

该数据集是TCGA乳腺癌侵袭性癌数据集合，整合了临床、遗传、病理和影像数据，旨在研究癌症基因型与影像表型及患者预后的关联。数据来源于全球多个站点，具有高度异质性，包括不同扫描设备、制造商和采集协议，且影像数据主要来自常规临床护理。