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Age- and ApoE genotype-dependent transcriptomic responses to O3 in the hippocampus of mice

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We earlier demonstrated that ozone an urban pollutant, accelerates AD-like neuropathology in aging male ApoE3 mice. In this study, we investigate hippocampal transcriptomic alterations in young and aged E3 and E4 mice following O<3> exposure to elucidate the molecular mechanisms underlying O<3>-induced AD pathology specifically in old E3 male mice.

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