The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis [RNA-seq]
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https://www.ncbi.nlm.nih.gov/sra/SRP331345
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The purpose of this study was to decipher the molecular function of ARID3A. We leveraged gene expression (RNA-Seq) and chromatin profiling (ATAC-Seq and CUT&RUN) to evaluate gene expression changes upon restoring Arid3a expression in the context of the Gata1s mutation and miR-125b overexpression Overall design: We induced Arid3a-FLAG protein using doxycyline in Gata1s-FLCs lentivirally expressing miR-125b
创建时间:
2022-04-23



