ESM Atlas — Protein Features and Structures

The ESM Atlas is a large-scale public dataset of computational outputs generated by ESMC and ESMFold2, derived from a deduplicated set of over 6.8 billion publicly available protein sequences spanning all domains of life — including viral proteins and previously unannotated sequences representing metagenomic dark matter sampled from a wide range of biomes. The dataset includes two primary components. A sparse autoencoder (SAE) features for ~6.8 billion proteins, capturing interpretable biological representations from the ESMC 6B model, and predicted three-dimensional protein structures for ~1....ESM图谱（ESM Atlas）是由ESMC与ESMFold2生成的大规模公开计算输出数据集，其源自去重后的超68亿条公开可用蛋白质序列，覆盖生命的所有域——包括病毒蛋白质，以及从多样生物群系中采样得到的、代表宏基因组暗物质的此前未注释序列。 该数据集包含两个核心组成部分：其一为针对约68亿条蛋白质的稀疏自编码器（SAE，sparse autoencoder）特征集，该特征集从ESMC 6B模型中提取出可解释的生物学表征；其二为约1...的预测蛋白质三维结构。