Detailed mutational analysis of the antibody interface (epitope and paratope). Change in stability and affinity predicted using FoldX, mCSM, ProAffiMuSeq, CUPSAT webservers/tools.
This project is being carried out through a Strategic Award from the Wellcome Trust to Steve Jackson, Mike Stratton, Peter Campbell, Serena Nik-Zainal and others. This grant is to fund work aimed at i