Prolonged water‐only fasting followed by a whole‐plant‐food diet promotes fat‐free mass recovery and continued fat mass loss in adults with overweight or obesity

Conventional weight-loss strategies often result in inadequate fat loss, poor sustainability, and unintended lean mass loss. Prolonged water-only fasting followed by dietary change may offer an effective alternative, but its impact on body composition remains underexplored.
This secondary analysis utilized dual-energy X-ray absorptiometry (DXA) to assess changes in fat-free mass (FFM), fat mass (FM), and bone mineral content (BMC) in adults [median (IQR) age: 62 (15) years] with overweight or obesity. Participants underwent a median (IQR) of 14 (6) days of water-only fasting, followed by 6 (3) days of food reintroduction with a whole-plant-food diet and a subsequent maintenance period of 45 (5) days. Study visits occurred at baseline and at the end of each period.
At the end of fasting, FFM accounted for 74% of the total BW lost during fasting. However, at the follow-up visit, the median (IQR) percentage change in total BW, FFM, FM, and visceral adipose tissue (VAT) mass from baseline w..., This study was a secondary analysis of data collected as part of a clinical trial (NCT04514146) that was approved by the TrueNorth Health Institutional Review Board in Santa Rosa, California (TNHF-2020-2VAT; April 2, 2020) and conducted according to the guidelines of the Declaration of Helsinki. The main study methods were previously published.31
Study Details
Participants were recruited from patients at a residential fasting center specializing in inpatient, medically supervised water-only fasting and whole-plant-food refeeding. Informed consent was obtained from all participants before enrollment and throughout the study. Forty participants were enrolled, of which 38 completed the on-site fasting and food reintroduction protocol, and the 29 participants presented here completed the full study protocol.31 As previously described, eligibility included males and females aged 40–70 years with a BMI between 25–40 kg/m2 and fasting glucose <7 mmol/L and/or hemoglobin A1c <7% who had i..., # Prolonged water‐only fasting followed by a whole‐plant‐food diet promotes fat‐free mass recovery and continued fat mass loss in adults with overweight or obesity

Dataset DOI: [10.5061/dryad.q2bvq83z8](10.5061/dryad.q2bvq83z8)

Data Files Included

* Prolonged_water‐only_fasting_dxa_data.csv

This dataset accompanies the manuscript listed above and includes body composition measurements collected using a Hologic DXA scanner. The purpose of the dataset is to document changes in fat mass, lean mass, and other key metrics during prolonged water-only fasting and structured whole-plant-food refeeding in humans. Data are shared to support reproducibility and enable secondary analyses.

**Experimental Summary**

* **Sample Size**: N=29
* The `record_ID` field has been anonymized and the dataset does not contain any direct or indirect identifiers.
* **Intervention:** Medically supervised prolonged water-only fasting (median duration: 14 days) followed by whole-plant-food refeeding (median dur..., This study was a secondary analysis of data collected as part of a clinical trial (NCT04514146) that was approved by the TrueNorth Health Institutional Review Board in Santa Rosa, California (TNHF‐2020‐2VAT; April 2, 2020) and conducted according to the guidelines of the Declaration of Helsinki. All participants provided written, ongoing consent.

传统减重策略往往难以实现理想的脂肪减少效果、可持续性差，且会造成非预期的瘦体重丢失。长期纯水禁食辅以膳食调整或可成为有效的替代方案，但目前学界对其对身体成分的影响仍研究不足。

本二次分析采用双能X线吸收测定法（dual-energy X-ray absorptiometry, DXA），评估超重或肥胖成年人[年龄中位数（四分位距）：62（15）岁]的去脂体重（fat-free mass, FFM）、脂肪量（fat mass, FM）及骨矿物质含量（bone mineral content, BMC）变化。受试者先后接受中位数（四分位距）为14（6）天的纯水禁食、6（3）天的全植物性食物复食，以及为期45（5）天的维持阶段。研究访视分别于基线期及各阶段结束时进行。

禁食结束时，去脂体重占禁食期间总体重丢失量的74%。然而在随访访视中，总体重、去脂体重、脂肪量及内脏脂肪组织（visceral adipose tissue, VAT）质量相较于基线的变化百分比中位数（四分位距）……

本研究为一项临床试验（临床试验编号：NCT04514146）的二次分析，该试验经加利福尼亚州圣罗莎市TrueNorth健康机构审查委员会批准（批准号：TNHF-2020-2VAT；2020年4月2日），并按照《赫尔辛基宣言》指南开展。主要研究方法已在既往文献中发表31。

## 研究详情
受试者招募自一家专注于住院式医学监督纯水禁食与全植物性食物复食的住宿式禁食中心。所有受试者在入组前及整个研究过程中均已签署知情同意书。本研究共纳入40名受试者，其中38名完成了现场禁食与复食方案，本文所纳入的29名受试者完成了全部研究流程31。如前所述，纳入标准包括年龄40~70岁的男性与女性，体重指数（body mass index, BMI）为25~40 kg/m²，空腹血糖<7 mmol/L和/或糖化血红蛋白A1c<7%，且……

# 长期纯水禁食辅以全植物性膳食可促进超重/肥胖成年人去脂体重恢复并持续减少脂肪量

数据集DOI：[10.5061/dryad.q2bvq83z8](10.5061/dryad.q2bvq83z8)

## 包含的数据文件
* Prolonged_water‐only_fasting_dxa_data.csv
本数据集配套于上述研究论文，包含使用Hologic DXA扫描仪采集的身体成分测量数据。本数据集旨在记录人类在长期纯水禁食及规范化全植物性食物复食过程中，脂肪量、瘦体重及其他关键指标的变化情况。公开本数据以支持研究可重复性，并为二次分析提供便利。

**实验概述**
* **样本量**：N=29
* `record_ID`字段已完成匿名化处理，本数据集不含任何直接或间接识别信息。
* **干预措施**：经医学监督的长期纯水禁食（中位时长：14天），随后辅以全植物性食物复食（中位时长……

本研究为临床试验（临床试验编号：NCT04514146）的二次分析，该试验经加利福尼亚州圣罗莎市TrueNorth健康机构审查委员会批准（批准号：TNHF‑2020‑2VAT；2020年4月2日），并遵循《赫尔辛基宣言》指南开展。所有受试者均已签署书面持续知情同意书。