Data and code for: Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis.

This repository contains the data and code required to reproduce the figures and analyses in Ziehr et al., "Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis," Science Translational Medicine (2025). The repository is structured as an R project with a targets pipeline. All package dependencies are managed with renv. To reproduce the analyses, restore the package environment with renv::restore() and execute the pipeline with targets::tar_make(). Processed RNA-seq and spatial transcriptomics data objects are available as companion data packages at https://doi.org/10.5281/zenodo.19198539 and https://doi.org/10.5281/zenodo.19244873, respectively. Raw data underlying the pipeline outputs are deposited in NCBI SRA under BioProject PRJNA1011992 (RNA-seq) and NCBI GEO under accession GSE325253 (spatial transcriptomics).本仓库包含复现Ziehr等人2025年发表于《科学·转化医学（Science Translational Medicine）》的论文《乳酸转运抑制可在实验性肺纤维化中治疗性重编程成纤维细胞代谢》一文中所有图表与分析所需的数据与代码。 本仓库采用R项目结构，并配置了targets工作流管线。所有R包依赖均通过renv进行管理。若需复现分析流程，请先通过`renv::restore()`恢复R包环境，再通过`targets::tar_make()`执行工作流管线。经过预处理的RNA测序（RNA-seq）与空间转录组学（spatial transcriptomics）数据对象分别以配套数据包的形式发布于以下链接：https://doi.org/10.5281/zenodo.19198539 与 https://doi.org/10.5281/zenodo.19244873。 本管线输出所依托的原始数据已分别提交至NCBI序列读取档案（NCBI SRA）的BioProject PRJNA1011992（对应RNA-seq数据），以及NCBI基因表达综合数据库（NCBI GEO）的登录号GSE325253（对应空间转录组学数据）。