Cell type distribution in female and male mouse brains / Pdyn_GFP_M9_191229

This project proposes to establish an Anatomical Collaboratory for Systematic Atlasing of Cell-Type Distribution and Morphology in female and male brain. This Collaboratory will apply standardized, unbiased and largely automated methods developed in the group’s laboratories to atlas the distribution and morphology of >80 molecularly defined cell classes and cell type across all regions of the female and male brain. This work will yield the most comprehensive characterization of cell type anatomy in the mammalian brain to date, establishing a structural basis for building an integrated Cell Type Brain Atlas.

本项目旨在构建一个针对雌性和雄性大脑中细胞类型分布与形态的系统图谱解剖协作实验室。该协作实验室将应用实验室自主研发的标准化、无偏倚且高度自动化的方法，对超过80种分子定义的细胞类型及其形态进行图谱绘制，涵盖雌性和雄性大脑的所有区域。此项研究将为哺乳动物大脑中细胞类型解剖的全面描述提供支持，并奠定构建集成细胞类型大脑图谱的结构基础。