AntigenDB: an immunoinformatics database of pathogen antigens

Welcome to the official repository for AntigenDB, a comprehensive and manually curated database of experimentally validated antigens from pathogenic organisms. This resource is designed to support researchers in vaccine development, immunoinformatics, computational vaccinology, and microbiology. Web Server: https://webs.iiitd.edu.in/raghava/antigendb/ Citation Ansari, H. R., Flower, D. R., & Raghava, G. P. S. (2010). AntigenDB: an immunoinformatics database of pathogen antigens. Nucleic Acids Research, 38 (Database issue), D847–D853. https://doi.org/10.1093/nar/gkp830 About the Database AntigenDB is a specialized, value-added database of experimentally validated antigens derived from pathogenic organisms. Unlike existing epitope-oriented databases (IEDB, MHCBN, AntiJen, BCIPEP), AntigenDB is antigen-centric — it covers all experimentally determined antigens regardless of whether epitope information is known, including the large class of protective antigens for which no epitope has yet been identified. The database integrates information from: Literature (PubMed, ScienceDirect) Public repositories (SwissProt, GenBank, PDB, GEO, IEDB, MHCBN, AntiJen, BCIPEP) Specialized databases (dbPTM, PhosphoELM, RESID, InterPro, DBSubLoc, PSORTdb, IMGT, SYFPEITHI) Key Features Massive Dataset Over 500 antigen entries (proteins, glycoproteins, and lipoproteins) Derived from 44 important pathogenic species Crystal structure data available for 290 out of 504 antigens欢迎来到AntigenDB的官方仓库，AntigenDB是一款经人工精准审校的综合性数据库，收录各类病原生物来源的经实验验证的抗原（antigen）。本数据库旨在为疫苗研发、免疫信息学（immunoinformatics）、计算疫苗学（computational vaccinology）及微生物学领域的科研人员提供学术支持。 官方网页服务地址：https://webs.iiitd.edu.in/raghava/antigendb/ 引用格式： Ansari, H. R., Flower, D. R., & Raghava, G. P. S. (2010). AntigenDB：病原体抗原免疫信息学数据库。《核酸研究（Nucleic Acids Research）》，38（数据库特刊），D847–D853。https://doi.org/10.1093/nar/gkp830 数据库概况 AntigenDB是一款针对病原生物来源的经实验验证抗原构建的专业化增值数据库。与现有以表位（epitope）为导向的数据库（IEDB、MHCBN、AntiJen、BCIPEP）不同，AntigenDB以抗原为核心：其收录所有经实验确定的抗原，无论是否包含其表位信息，涵盖了目前尚未鉴定出表位的大量保护性抗原类别。 本数据库整合了来自以下渠道的信息： - 学术文献库（PubMed、ScienceDirect） - 公共资源数据库（SwissProt、GenBank、PDB、GEO、IEDB、MHCBN、AntiJen、BCIPEP） - 专业细分数据库（dbPTM、PhosphoELM、RESID、InterPro、DBSubLoc、PSORTdb、IMGT、SYFPEITHI） 核心特征 海量数据集 - 收录超500条抗原条目，涵盖蛋白质（protein）、糖蛋白（glycoprotein）与脂蛋白（lipoprotein） - 数据来源于44种重要病原生物物种 - 504个抗原中，290个配有公开晶体结构数据