Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be

NuMoM2b studied underlying, interrelated, mechanisms of adverse pregnancy outcomes (e.g., preterm birth, preeclampsia, fetal growth restriction) in pregnant women with no previous pregnancy lasting 20 weeks-0 days or more estimated gestational age (nulliparas). The network included 8 clinical sites, subsites, NICHD, and a data center. Women enrolled early in pregnancy and were followed through delivery, with study visits at 6 weeks-0 days to 13 weeks-6 days, 16 weeks-0 days to 21 weeks-6 days, 22 weeks-0 days to 29 weeks-6 days gestation, and delivery. Data collected through interviews, self-administered questionnaires, clinical measurements, ultrasounds, and medical records review included demographic, psychosocial, dietary, physiologic, health, and pregnancy outcome information. Subsets of participants enrolled in sleep disordered breathing, sleep patterns and quality, and fetal adrenal gland substudies.

搜集汇总

背景与挑战

背景概述

该数据集是美国国家儿童健康与人类发展研究所（NICHD）开展的一项多中心临床研究，聚焦于初产妇（无既往怀孕20周以上经历）的不良妊娠结局机制，如早产、子痫前期和胎儿生长受限。研究招募了9,289名女性参与者，在怀孕早期至分娩期间进行了多次随访，收集了人口统计学、心理社会、饮食、生理等多维度数据，并包含睡眠障碍等子研究，数据以访谈、问卷、临床测量和超声等形式记录，部分数据因参与者同意限制未完全公开。