Integrating three datasets of postpartum haemorrhage

We harmonized four anonymized datasets. ANDERCAISM: the first dataset was obtained from CAISM Women’s Hospital, a tertiary referral maternity center in Brazil, and contains detailed, high-resolution clinical and hemodynamic data of 270 women, including measurements of blood loss and vital signs recorded every 5 to 15 minutes during the first two hours postpartum1 The additional datasets consisted of 2,390 postpartum cases pooled from three independent studies named after their abbreviations ADBRCT2, FAUOSMFT3, AND TRCTOM4 described below. Anonymized data from these studies were retrieved from the website https://dataverse.harvard.edu/ ADBRCT: A double-blind, randomized controlled trial conducted in Argentina comparing intravenous (IV) versus intramuscular (IM) oxytocin administration during the third stage of labor (n = 543), with blood loss measured using calibrated receptacles for a minimum of one hour postpartum.20 FAUOSMFT: Fever after use of sublingual misoprostol for treatment of postpartum hemorrhage: A prospective observational study evaluating the side effect profile of sublingual misoprostol for PPH treatment in Corrientes, Argentina (n = 49).21 TRCTOM: Two large, double-blind, randomized, placebo-controlled non-inferiority trials comparing sublingual misoprostol with intravenous oxytocin for PPH treatment across multiple LMIC settings, including Argentina and other countries (n = 1,787).22 Each study used standardized protocols for blood loss estimation and adhered to a consistent clinical definition of PPH as blood loss ≥500 mL. While not all external studies captured blood loss at high temporal resolution, they contained overlapping predictors with the internal CAISM dataset, which allowed for harmonization and external validation of predictive models using a reduced but comparable feature set. 1 - Pacagnella, R. C., Borovac‐Pinheiro, A., Silveira, C., Siani Morais, S., Argenton, J. L. P., Souza, J. P., Weeks, A. D., & Cecatti, J. G. (2022). The golden hour for postpartum hemorrhage: Results from a prospective cohort study. International Journal of Gynecology & Obstetrics, 156(3), 450–458. https://doi.org/10.1002/ijgo.13823 2. Durocher J. A double-blind, randomized controlled trial on oxytocin route for prevention of postpartum hemorrhage in Argentina. HAVARD DATAVERSE. https://doi.org/10.7910/DVN/MDZRKU 3. Durocher J. Fever after use of sublingual misoprostol for treatment of postpartum hemorrhage: A prospective, observational study conducted in two hospitals in Argentina". HAVARD DATAVERSE. https://doi.org/10.7910/DVN/GBKWCE 4. Winikoff B. Two randomized controlled trials of misoprostol for the treatment of postpartum hemorrhage. HAVARD DATAVERSE. Published online 2019. https://doi.org/10.7910/DVN/ETHH4N