Data from: High reproducibility of adenosine stress cardiac magnetic resonance myocardial perfusion imaging in patients with nonischemic dilated cardiomyopathy

Objective: To evaluate the reproducibility of first-pass contrast-enhanced cardiac magnetic resonance (CMR) myocardial perfusion imaging in nonischemic dilated cardiomyopathy (NIDCM) patients. Design: Prospective observational study Setting: Single center, tertiary care hospital Participants: Six outpatient participants with NIDCM Outcome: Reproducibility of semi-quantitative myocardial perfusion analysis by CMR Method: Six NIDCM patients were studied twice using first-pass of contrast transit through the left ventricular (LV) myocardium with a saturation-recovery gradient echo sequence at rest and during adenosine-induced hyperemia. The anterior wall was divided into endocardial (Endo) and epicardial (Epi) segments. The myocardial perfusion index (MPI) was calculated as the myocardial signal augmentation rate normalized to the LV cavity rate. The myocardial perfusion reserve index (MPRI) was calculated as hyperemic/resting MPI. Results: Between Study 1 and 2, median MPI was similar for resting Endo (0.076 vs. 0.077), hyperemic Endo (0.143 vs. 0.143), resting Epi (0.073 vs. 0.074), and hyperemic Epi (0.135 vs. 0.134). Median MPRI was similar for Endo (1.84 vs. 1.87) and Epi (1.90 vs. 2.00). Combining Endo and Epi MPI (N=12), there was excellent agreement between Study 1 and 2 for resting MPI (r=0.998, ICC 0.998, CoV 1.4%), hyperemic MPI (r=0.979, ICC 0.963, CoV 3.3%), and MPRI (r=0.989, ICC 0.94, CoV 3.8%). Conclusion: Resting and hyperemic myocardial perfusion using a normalized upslope analysis during adenosine CMR is a highly reproducible technique in NIDCM patients. Clinical Trials.Gov ID NCT00574119.

研究目的：评估非缺血性扩张型心肌病（nonischemic dilated cardiomyopathy, NIDCM）患者首次通过对比增强心脏磁共振（cardiac magnetic resonance, CMR）心肌灌注成像的可重复性。
研究设计：前瞻性观察性研究。
研究场景：单中心三级医院。
研究对象：6名非缺血性扩张型心肌病门诊患者。
研究结局：心脏磁共振半定量心肌灌注分析的可重复性。
研究方法：对6名非缺血性扩张型心肌病患者进行两次扫描，分别在静息状态及腺苷诱导充血状态下，采用饱和恢复梯度回波序列，完成对比剂首次通过左心室（left ventricular, LV）心肌的成像。将前壁分为心内膜（endocardial, Endo）与心外膜（epicardial, Epi）节段。以心肌信号增强速率相对于左心室腔信号增强速率进行归一化，计算得到心肌灌注指数（myocardial perfusion index, MPI）；以充血状态与静息状态下的MPI比值计算得到心肌灌注储备指数（myocardial perfusion reserve index, MPRI）。
研究结果：两次扫描间，静息状态心内膜节段的MPI中位数分别为0.076与0.077，充血状态心内膜节段分别为0.143与0.143，静息状态心外膜节段分别为0.073与0.074，充血状态心外膜节段分别为0.135与0.134，上述指标均无显著差异。心内膜节段的MPRI中位数分别为1.84与1.87，心外膜节段分别为1.90与2.00，同样无显著差异。合并心内膜与心外膜节段的MPI数据（共12组样本）后，两次扫描的静息MPI（相关系数r=0.998，组内相关系数ICC=0.998，变异系数CoV=1.4%）、充血MPI（r=0.979，ICC=0.963，CoV=3.3%）及MPRI（r=0.989，ICC=0.94，CoV=3.8%）均具有极佳的一致性。
研究结论：在腺苷负荷心脏磁共振检查中，采用归一化上升速率分析的静息与充血状态心肌灌注技术，在非缺血性扩张型心肌病患者中具有极高的可重复性。本研究临床试验注册号为ClinicalTrials.gov ID NCT00574119。