Tissue-specific insulin resistance indices and fasting plasma insulin as predictors of incident type 2 diabetes in the 5.9-years METSIM prospective study, Kuopio, Finland.

Abbreviations: CI, confidence interval; HR, hazard ratio; IR, insulin resistance.
HRs and their 95% CI were obtained from Cox regression analyses. HRs were calculated using standardized predictors (unit = one standard deviation). Individuals with type 1 diabetes (N = 25), type 2 diabetes (N = 763) or newly diagnosed type 2 diabetes at baseline (N = 649) were excluded. A total of 558 individuals were diagnosed with incident type 2 diabetes during the 5.9 year follow-up, 8,191 participants remained non-diabetic. Bold font indicates statistical significance P<0.0125.
P, unadjusted.
Pa, adjusted for age, BMI, smoking, physical activity, alcohol consumption and family history of type 2 diabetes.
Pb, adjusted for age, BMI, smoking, physical activity, alcohol consumption, family history of type 2 diabetes and disposition index at baseline.
Pc, adjusted for age, BMI, smoking, physical activity, alcohol consumption, family history of type 2 diabetes and glucose AUC at baseline.
Pd adjusted for age, BMI, smoking, physical activity, alcohol consumption, family history of type 2 diabetes, disposition index and glucose AUC at baseline.
*Matsuda IR was calculated as: 10/Matsuda ISI.
Disposition index was calculated as: Matsuda ISI×InsAUC0–30/GluAUC0–30.
Tissue-specific insulin resistance indices and fasting plasma insulin as predictors of incident type 2 diabetes in the 5.9-years METSIM prospective study, Kuopio, Finland.