Analysis of posttranscriptional mechanisms in innate immunity.

Gene expression in response to inflammatory stimuli is controlled by both transcriptional and posttranscriptional mechanisms in immune cells. Posttranscriptional regulation that modifies mRNA stability and translation provides rapid and flexible control of gene expression and control of mRNAs stability is important for coordinating the initiation and resolution of inflammation. However, the posttranscriptional mechanisms in innate immunity remain to be clarified. This study is aiming to investigate the posttranscriptional mechanisms in innate immunity based on the roles of RNA binding proteins and RNase we identified.