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H3K36me3 protects the mouse epigenome from single nucleotide variations [mRNA-Seq]

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE99155
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The goals of this project are to study the transcriptome profiling (RNA-seq) of mouse embryonic stem cells by histone mutants incorporation (H3.1K3M, H3.1K36M vs H3.1wt) or shRNA-mediated knockdown of methyl-transferase Suv39h1/h2 (shSuv39h1, shSuv39h2 vs shNC) mRNA profiles of mES stable cell lines with overexpression of H3.1WT, H3.1K9M, H3.1K36M and shNC, shSuv39h1, shSuv39h2 were generated by deep sequencing, in double, using Illumina next-generation sequencing.
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2021-07-25
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