Gut microbiota profiling following antibiotic-induced dysbiosis in mice

This project investigates the alterations in gut microbial composition following broad-spectrum antibiotic treatment in mice. Using 16S rRNA gene sequencing, we assessed the impact of antibiotic-induced dysbiosis on microbial diversity, taxonomic composition, and short-chain fatty acid producing bacteria. Significant reductions in alpha diversity and shifts in microbial community structure were observed, including depletion of commensal butyrate-producing taxa such as Lachnospiraceae and Ruminococcaceae. These findings highlight the substantial alterations in gut microbial structure and diversity caused by antibiotic treatment, which may have important implications for host immune function and metabolic balance.