Sequence-based discovery of a cord colitis syndrome-associated Bradyrhizobium. Bradyrhizobium sp. DFCI-1

The goal of this project was to identify a potential bacterial cause of a stem-cell transplantation colitis syndrome called cord colitis syndrome. DNA sequencing of colon biopsy samples of affected patients was performed and the non-human sequences were assembled to identify any novel organisms associated with the disease. This approach resulted in the assembly of a draft genome of a strain isolated from two temporally separated colonic biopsies of a single patient with cord colitis syndrome.